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Glutamate and neurotrophic factors in neuronal plasticity and disease

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In vitro studies, Tan IIA (1,3 and 10 μM) downregulated the expression of SR-A and upregulated the expression of ABCA1 and ABCG1 by activating the ERK/Nrf2/HO-1 signaling pathway, thereby inhibiting ox-LDL-induced cholesterol accumulation in THP-1 macrophages (Liu et al., 2014)

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